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Oxidação dos ácidos gordos

A descoberta do destino dos ácidos gordos nas mitocôndrias de fígado aconteceu após o final da Segunda Guerra Mundial. Foi publicada por Albert Lehninger (sim, o autor do livro) e Eugene Kennedy em 1948. Umas palavras do referido artigo:

[...] The oxidation of n-octanoate in these suspensions was found to proceed according to the equation, C7H15COOH + 3 O2 --> 2 CH3COCH2COOH + 2 H2O. However, when the oxidation was allowed to take place in the presence of oxalacetate, the yield of acetoacetate diminished and citrate accumulated, implicating the Krebs tricarboxylic acid cycle in fatty acid oxidation in these enzyme preparations. The latter study also yielded some information as to certain features of the mechanism of fatty acid oxidation, supplementing the isotope studies of Weinhouse and his colleagues (3, 4) and Buchanan et al. (5). The gross mechanism of oxidation in the liver of the rat, at least, appears to involve the successive oxidative removal of 2-carbon units from the fatty acid. [...]
(op. cit., p. 753)

Albert L. Lehninger and Eugene P. Kennedy (1948). THE REQUIREMENTS OF THE FATTY ACID OXIDASE COMPLEX OF RAT LIVER. J. Biol. Chem. 173: 753-771.

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